GWC
Technologies
505 S. Rosa Rd
Madison, WI 53719
USA 
608.441.2726
 

LOOK WHO IS USING GWC’S PRODUCTS

Cancer Researchers Arthur Polans, PhD and Lalita Subramanian, PhD, Dept. of Ophthalmology & Visual Sciences, and Dept. of Biomolecular Chemistry, University of Wisconsin-Madison, USA.
Dr. Polans' research group studies molecular pathways involved
Annexin
in the development of uveal melanoma, the primary malignancy of the eye. A recent study characterized the role of certain calcium-binding proteins in this disease. ALG-2, a calcium-binding protein involved in programmed cell death, is down-regulated in uveal melanoma. Dr. Polans’ group used the SPRimager®II to study interactions between ALG-2 and the protein Annexin XI. The team obtained more reproducible measurements of this calcium-dependent protein-protein interaction using the SPRimager®II platform than with a vastly more expensive SPR instrument. The superior result is likely due to the dextran-free surface used for the SPRimager®II analysis, which allowed for more stable immoblization of Annexin XI.
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