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GWC
Technologies |
505
S. Rosa Rd
Madison, WI 53719
USA |
| 608.441.2726 |
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LOOK WHO IS
USING GWC’S PRODUCTS |
Cancer
Researchers Arthur Polans, PhD and Lalita Subramanian, PhD,
Dept. of Ophthalmology & Visual Sciences, and Dept. of Biomolecular
Chemistry, University of Wisconsin-Madison, USA.
Dr. Polans' research group studies molecular pathways involved
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| Annexin |
in the development of uveal melanoma,
the primary malignancy of the eye. A recent study characterized
the role of certain calcium-binding proteins in this disease.
ALG-2, a calcium-binding protein involved in programmed cell
death, is down-regulated in uveal melanoma. Dr. Polans’
group used the SPRimager®II to study interactions between
ALG-2 and the protein Annexin XI. The team obtained more reproducible
measurements of this calcium-dependent protein-protein interaction
using the SPRimager®II platform than with a vastly more
expensive SPR instrument. The
superior result is likely due to the dextran-free surface
used for the SPRimager®II analysis, which allowed for more
stable immoblization of Annexin XI. |
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GWC Technologies
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